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It is in the serotonin-antagonist-and-reuptake-inhibitor class of medications. It is often used in combination with other drugs to help reduce anxiety Abstract. Trazodone comes in a tablet and an extended-release tablet Trazodone was approved for medical use in the United States in 1981. [18] In 2019, it was the 25th most commonly prescribed medication in the United States, with more than 23 million prescriptions. FSA or HSA eligible TRAZODONE: The Effective Antidepressant Medication for Treatment of Major Depressive Disorder, Anxiety Disorder, Insomnia and Alcohol Dependence. [23] [24] Contents 1 Medical uses 1. Books & More; Curbside Pickup Appointments. TRAZODONE (Desyrel) is an antidepressant, a medicine that helps to lift mental depression. It can help patients whose depression has not responded to other medications, or who have experienced limiting side effects with other antidepressants. 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