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The tablet may be split in half. Make sure you are fully vaccinated before traveling to Lebanon. Yes, the long-term use of Xyzal ( levocetirizine ), a 'third-generation" antihistamine, is considered to be safe for most people. Do not take more medicine than directed. 5 mg, if needed You can purchase Xyzal without a prescription between and depending on strength and count. Levocetirizine works by reducing the effects of a natural chemical in the body called histamine. Xyzal is in a drug class called antihistamines. Medicaid Services (CMS) has also launched an outreach and an educational campaign, which includes broadcast and digital advertising and educates through email and text messages in both Spanish and English.. XELJANZ Worldwide Registration Status. Although both are considered nonsedating antihistamines, both Xyzal and Zyrtec have drowsiness as a potential side effect. 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